Neurobiology of Disease APOE4 Allele Disrupts Resting State fMRI Connectivity in the Absence of Amyloid Plaques or Decreased CSF A 42
نویسندگان
چکیده
Yvette I. Sheline,1,2,3,6 John C. Morris,3,6 Abraham Z. Snyder,2 Joseph L. Price,4 Zhizi Yan,2 Gina D’Angelo,5,6 Collin Liu,2 Sachin Dixit,2 Tammie Benzinger,2 Anne Fagan,3,6 Alison Goate,1,3,6 and Mark A. Mintun1,2,6 Departments of 1Psychiatry, 2Radiology, 3Neurology, 4Anatomy and Neurobiology, and 5Biostatistics, and 6The Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, Missouri 63110
منابع مشابه
APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42.
Identifying high-risk populations is an important component of disease prevention strategies. One approach for identifying at-risk populations for Alzheimer's disease (AD) is examining neuroimaging parameters that differ between patients, including functional connections known to be disrupted within the default-mode network. We have previously shown these same disruptions in cognitively normal ...
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